Often you will need to temporarily exit Guild Wars 2 to look at a file or a browser window on your computer. To do so, hold down the Command key and push Tab (Macs) or hold down the Windows key and push Tab (PCs). This minimizes the screen.
http://www.guildwars2guru.com/arenanet-tracker/topic/236488-altwindows-key-tab-closes-the-game/
Pushing the same key sequence again should take you back to a full Guild Wars 2 window although it may take a few key combo pushes to cycle through the open applications to get back to GW2.
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